Fmoc-alpha-Et-D-Ala-OH USED IN API MANUFACTURING,CAS NO 857478-30-9Fmoc-alpha-Et-D-Ala-OH,Fmoc-alpha-Et-D-Ala-OH Fmoc Protect Amino Acids Ronas Chemicals Ind. Co.,Ltd. , https://www.ronaschemical-cn.com
In recent years, China has emerged as the largest producer and consumer of plasticizers in Asia. As global environmental awareness grows, industries such as pharmaceuticals, food packaging, personal care products, and toys are demanding higher purity and hygiene standards for key plasticizers like DOP (di(2-ethylhexyl) phthalate). However, the majority of plasticizers currently produced by domestic companies still lack the necessary safety and environmental compliance, especially in terms of low toxicity and hygienic performance.
The potential health risks associated with DOP have drawn significant international attention. Although debates continue regarding its carcinogenicity, many countries have taken precautionary measures due to its possible harmful effects. For example, the U.S. Environmental Protection Agency (EPA) has banned the production of six new phthalates, and DOP is now restricted to use in high-water-content food packaging. Meat packaging must now use non-toxic alternatives. According to studies from Japan, South Korea, and other nations, DOP (DEHP) is more hazardous than DOA (DEHA). The European Food Safety Authority (EFSA), for instance, sets a stricter limit for DEHP at 0.05 mg/kg compared to 0.3 mg/kg for DEHA, highlighting the greater risk posed by DOP.
Both DOA and DOP are widely used in China’s polyvinyl chloride (PVC) food wrap. While DOA is considered safer, it is more expensive, leading most manufacturers to rely on DOP and DBP. This poses a serious concern, especially when wrapping fatty foods or meat that may be heated in a microwave. Under such conditions, the likelihood of plasticizer migration into food increases, potentially posing health risks. However, using PVC wraps for vegetables or raw ingredients before cooking is generally considered safer.
Internationally, strict regulations have been imposed on DOP. The U.S. has halted the industrial production of several phthalates, while Switzerland has banned DOP in children’s toys. Germany prohibits its use in all food-related plastic products, and Japan restricts DOP to industrial applications only. Globally, there is an accelerated push toward developing non-toxic plasticizer alternatives, particularly for products requiring high hygiene standards.
In China, however, DOP and DBP still dominate the market, largely due to their low cost. Despite being phased out in many foreign markets, these substances remain widely used. The national standard for food packaging materials still permits the use of DOP, although this is under increasing scrutiny. Domestic manufacturers have not yet fully embraced the development and promotion of safer, non-toxic alternatives, which remains a critical challenge for the industry.
October 08, 2025